|
DIOPT Diseases and Traits (DIOPT-DIST) is a spin-off of our DIOPT tool for identification of orthlogs. DIOPT-DIST make one more connection to link from model species to human genome to disease-associated genes.
Search with a disease and generate an output list of corresponding yeast, worm, zebrafish, mouse or fly orthologs of the disease-associated human genes. Or, search with a yeast, worm, zebrafish, mouse or fly gene(s) and get a list of human gene orthologs of your input that have been associated through genetic study or GWAS with diseases or traits.
Go to DIOPT-DIST.
Our sources for disease-gene links include the NCBI Online Mendelian Inheritance in Man (OMIM) resource and the NHGRI archive of genome-wide association study (GWAS) data.
Read more about it in Hu Y, Flockhart I, Vinayagam A, Bergwitz C, Berger B, Perrimon N, Mohr SE. An integrative approach to ortholog prediction for disease-focused and other functional studies. BMC Bioinformatics. 2011 Aug 31;12:357. PubMed PMID: 21880147; PubMed Central PMCID: PMC3179972
|
|
